A new measure for the strength of electrical synapses

A new measure for the strength of electrical synapses

Blog Article

Electrical synapses, like chemical synapses, mediate intraneuronal communication.Electrical synapses are typically quantified by subthreshold measurements of coupling, which fall short in describing their impact on spiking activity in coupled neighbors.Here we describe a novel measurement for electrical synapse strength that nitrile gloves in a bucket directly evaluates the effect of synaptically transmitted activity on spike timing.This method, also applicable to neurotransmitter-based synapses, communicates the considerable strength of electrical synapses.For electrical synapses measured in rodent slices of the thalamic reticular nucleus, spike timing is modulated by read more tens of ms by activity in a coupled neighbor.